You're not getting a basic groupoff an acidic carbon without a fight, and acids, borohydride, andLiAlhydride aren't gonna fight that hard.SYNTHESES THAT DON'T SUCK:One of the easiest ways to make methamphetamine is from amphetamine Ofcourse, this assumes you have amphetamine in the first place, but let'sjust pretend you have some and you want to spice it up a bit.The difference between amphetamine and methamphetamine is the addition ofa single methyl group (CH3) to the amino group sticking off the middlecarbon atom in the chain. If the hydroxyl were on the second carbon from the ring (thecarbon with the amine group, the NH2 or NHCH3), there might be somechance, but it's not and there's not.
Thisis because the hydroxyl group (the OH in ephedrine) is on a very acidiccarbon (the first carbon away from the ring) and a hydroxyl group is verybasic.
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